2-methyloxolane (2-MeOx) as sustainable lipophilic solvent to substitute hexane for green extraction of natural products. Properties, applications, and perspectives

Rapinel V. · Molecules · 2020 · 70 citations

Can we finally ditch petroleum-based hexane for a greener, bio-based alternative in natural product extraction? Meet 2-methyloxolane, a sustainable solvent reshaping modern plant chemistry.

The quest to replace conventional petroleum-based solvents is heating up across modern plant-based chemistry. This comprehensive review dives deep into 2-methyloxolane, known as 2-MeOx, showcasing its potential as a bio-based champion for extracting natural products and food ingredients. Scientists are closely examining everything from its intrinsic solvent power and extraction efficiency to its detailed toxicological profile and environmental footprint.

When squared off against hexane—the heavy-hitter of petroleum-based solvents used for extracting lipophilic compounds—2-MeOx holds its own. The review doesn't just stop at the laboratory bench; it bridges the gap to real-world application. It tackles the nitty-gritty of successful industrial transfer, carefully weighing technological feasibility, economic viability, and safety impacts.

Ultimately, all reported applications point to a promising conclusion. 2-MeOx stands tall as an environmentally and economically sound alternative to conventional petroleum solvents when extracting lipophilic foodstuffs and natural treasures.

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