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Supercritical fluid extraction of bioactive compounds

da Silva R.P.F.F. · Trac Trends in Analytical Chemistry · 2016 · 646 citations

What if the ultimate green extraction method could capture nature's most valuable compounds without thermal degradation or messy solvents? The answer lies in the power of supercritical fluid technology.…

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Subcritical water extraction of natural products

Cheng Y. · Molecules · 2021 · 346 citations

What if ordinary water could transform into a green chemical solvent just by turning up the heat and pressure? This is the secret behind subcritical water extraction, a powerful eco-friendly technique reshaping how we harvest nature's chemistry.…

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The perspectives of natural deep eutectic solvents in agri-food sector

Mišan A. · Critical Reviews in Food Science and Nutrition · 2020 · 293 citations

What if the future of eco-friendly food processing relies on green liquids derived straight from nature? As the agri-food sector demands safer practices and 'clean-labeled' products, natural deep eutectic solvents (NADES) are stepping up as a compelling alternative to toxic chemi…

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Utilization of natural deep eutectic solvents and ultrasound-assisted extraction as green extraction technique for the recovery of bioactive compounds from date palm (Phoenix dactylifera L.) seeds: An investigation into optimization of process parameters

Osamede Airouyuwa J. · Ultrasonics Sonochemistry · 2022 · 136 citations

What happens when you combine eco-friendly designer solvents with sound waves to unlock the hidden treasure inside discarded date palm seeds? Science reveals a remarkably efficient way to harvest powerful antioxidants.…

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Ultrasonic-assisted extraction of polyphenolic compounds from Paederia scandens (Lour.) Merr. Using deep eutectic solvent: optimization, identification, and comparison with traditional methods

Liu Y. · Ultrasonics Sonochemistry · 2022 · 94 citations

What happens when you combine sound waves with custom-designed green solvents to harvest nature's hidden chemical treasures? Researchers found a remarkably efficient way to unlock powerful antioxidants from a traditional medicinal herb.…

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Valorization of seabuckthorn pomace to obtain bioactive carotenoids: An innovative approach of using green extraction techniques (ultrasonic and microwave-assisted extractions) synergized with green solvents (edible oils)

Sharma M. · Industrial Crops and Products · 2022 · 102 citations

What if food waste could be transformed into brilliant natural pigments using nothing more than sound waves, microwaves, and everyday cooking oils? Researchers are turning discarded seabuckthorn pomace into a goldmine of health-boosting compounds.…

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Obtaining green extracts rich in phenolic compounds from underexploited food by-products using natural deep eutectic solvents. Opportunities and challenges

Palos-Hernández A. · Sustainable Chemistry and Pharmacy · 2022 · 99 citations

Can potato peels and olive leaves hold the secret to greener, more sustainable bioactive extraction? As environmental awareness surges, science is turning its attention to cleaning up how we harvest valuable compounds from what we throw away.…

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Pressurized hot water extraction of bioactives

Plaza M. · Trac Trends in Analytical Chemistry · 2023 · 54 citations

What if the key to unlocking nature's most valuable compounds was simply hot water under pressure? It's a technique that could replace toxic solvents with a sustainable, green alternative.…

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Physicochemical properties of choline chloride-based natural deep eutectic solvents (Nades) and their applicability for extracting oil palm flavonoids

Zain M.S.C. · Sustainability Switzerland · 2021 · 71 citations

What if agricultural waste could be unlocked using designer green liquids that are safe for cells yet powerful enough to extract valuable plant compounds? Researchers are turning to customized natural deep eutectic solvents to transform oil palm leaves into a goldmine of bioactiv…

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Green and Non‐conventional Extraction of Bioactive Compounds from Olive Leaves: Screening of Novel Natural Deep Eutectic Solvents and Investigation of Process Parameters

Ünlü A.E. · Waste and Biomass Valorization · 2021 · 67 citations

What if an everyday agricultural waste held the key to capturing powerful compounds like oleuropein, a molecule gaining intense attention for its anti-viral activity against SARS-CoV-2? Scientists are now turning to next-generation green chemistry to unlock this hidden potential.…

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Green and highly extraction of phenolic compounds and antioxidant capacity from kinkeliba (Combretum micranthum G. Don) by natural deep eutectic solvents (NADESs) using maceration, ultrasound-assisted extraction and homogenate-assisted extraction

Zannou O. · Arabian Journal of Chemistry · 2022 · 59 citations

Can a custom-built green liquid unlock the hidden antioxidant power of a celebrated tropical plant better than conventional chemistry? Researchers put natural deep eutectic solvents to the test on dried kinkeliba leaves, and the results rewrite how we extract nature's most valuab…

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A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study

Mostafa H. · Ultrasonics Sonochemistry · 2022 · 54 citations

Date seeds are waste no more—scientists have turned them into tiny nanoparticles packed with antioxidants, using a simple acid bath and sound waves. This study shows how to unlock their hidden power for functional foods.…

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Carboxylic acid-based deep eutectic solvents combined with innovative extraction techniques for greener extraction of phenolic compounds from sumac (Rhus coriaria L.)

Zannou O. · Journal of Applied Research on Medicinal and Aromatic Plants · 2022 · 52 citations

What if the secret to greener extraction lies in a simple mix of natural acids? A new study shows that carboxylic acid-based NADES can outperform traditional solvents in pulling phenolic compounds from sumac—and do it faster.…

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Advancing green extraction of bioactive compounds using deep eutectic solvent-based ultrasound-assisted matrix solid-phase dispersion: Application to UHPLC-PAD analysis of alkaloids and organic acids in Coptidis rhizoma

Han M. · Talanta · 2024 · 52 citations

Rosemary is a medicinal powerhouse, but how do we unlock its full potential? A new study pits four extraction techniques against each other to find the greenest, most effective way to harvest its health-boosting compounds.…

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Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods

Sakti A.S. · Heliyon · 2019 · 50 citations

Imagine a solvent that is green, safe, and yet outperforms traditional methods—this is the promise of Natural Deep Eutectic Solvents. A new study shows they can unlock more of the precious compounds in Indonesian cinnamon and sappan wood than ever before.…

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Development of a colorlessCentella asiatica(L.) Urb. extract using a natural deep eutectic solvent (NADES) and microwave-assisted extraction (MAE) optimized by response surface methodology

Phaisan S. · Rsc Advances · 2021 · 45 citations

What if the greenest way to extract a skincare superstar also produced a better, clearer result? A new process swaps harsh solvents for a natural eutectic mixture and microwaves, delivering higher yields of active compounds from Centella asiatica.…

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Green extraction of essential oils from Pistacia lentiscus resins: Encapsulation into Niosomes showed improved preferential cytotoxic and apoptotic effects against breast and ovarian cancer cells

Fahmy S.A. · Journal of Drug Delivery Science and Technology · 2023 · 44 citations

What if a centuries-old tree resin could be transformed into a targeted weapon against cancer? Scientists have found a way to wrap its essential oils in tiny bubbles, boosting their power against breast and ovarian cancer cells.…

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Chemical, Antioxidant, and Antimicrobial Properties of the Peel and Male Flower By-Products of Four Varieties of Punica granatum L. Cultivated in the Marche Region for Their Use in Cosmetic Products

Gigliobianco M.R. · Antioxidants · 2022 · 42 citations

Pomegranate peels and male flowers are not waste—they are a treasure trove of bioactive compounds that could revolutionize cosmetics. A new study reveals these by-products are packed with antioxidants and antimicrobial power, offering a greener path for beauty products.…

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Green extraction of hemp (Cannabis sativa L.) using microwave method for recovery of three valuable fractions (essential oil, phenolic compounds and cannabinoids): a central composite design optimization study

Mazzara E. · Journal of the Science of Food and Agriculture · 2022 · 41 citations

What if the waste from hemp essential oil production could be turned into a goldmine of bioactive compounds? A new study shows how a simple, solvent-free microwave method can extract not just oil, but also valuable phenolics and cannabinoids from the same plant.…

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Ultrasound assisted natural deep eutectic solvents based sustainable extraction of Spirulina platensis and orange peel extracts for the development of strawberry-cantaloupe based novel clean-label functional drink

Chaudhary K. · Ultrasonics Sonochemistry · 2025 · 37 citations

What if your next sip of strawberry-cantaloupe juice could be both a science experiment and a sustainability win? Scientists are now using ultrasound and natural solvents to turn algae and orange peels into a clean-label drink that's as smart as it is tasty.…

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Designing green and recyclable switchable supramolecular deep eutectic solvents for efficient extraction of flavonoids from Scutellariae Radix and mechanism exploration

Zhang Y. · Journal of Chromatography A · 2024 · 32 citations

What if the key to unlocking nature's hidden medicines lies in a solvent that can be recycled like a coffee cup? This study introduces a green, switchable deep eutectic solvent that efficiently extracts flavonoids from a traditional Chinese herb—and then conveniently returns to i…

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Simultaneous quantitative screening of 53 phytochemicals from Rheum tataricum L. roots: a comparative study of supercritical CO2, subcritical ethanol, and ultrasound-assisted extraction for enhanced antioxidant, antibacterial activities, and molecular docking study

Amangeldinova M. · Frontiers in Plant Science · 2024 · 31 citations

What if the key to powerful new antioxidants and antibiotics was hiding in a desert rhubarb root? Scientists just screened 53 phytochemicals from Rheum tataricum using green extraction methods—and the results are promising.…

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Selectivity Tuning by Natural Deep Eutectic Solvents (NADESs) for Extraction of Bioactive Compounds from Cytinus hypocistis—Studies of Antioxidative, Enzyme-Inhibitive Properties and LC-MS Profiles

Zengin G. · Molecules · 2022 · 29 citations

What if the secret to unlocking a parasitic plant's healing powers lies in a simple, natural solvent—not harsh chemicals? Cytinus hypocistis, a Mediterranean botanical oddity, just met its perfect match: Natural Deep Eutectic Solvents (NADESs).…

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The influence of natural deep eutectic solvents on bioactive natural products: studying interactions between a hydrogel model and Schisandra chinensis metabolites

Liu Y. · Fitoterapia · 2018 · 28 citations

What if a simple, eco-friendly solvent could unlock the hidden power of medicinal plants? Natural Deep Eutectic Solvents (NADES) are doing just that, and a new study shows how they can carry lipophilic molecules into a hydrogel—potentially revolutionizing drug delivery.…

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Efficient and green ultrasonic-assisted extraction of flavonoids from Sophorae Tonkinensis Radix Et Rhizoma using deep eutectic solvent: Optimization and extraction mechanism

Luo J. · Industrial Crops and Products · 2025 · 28 citations

What if the secret to greener medicine extraction lies in a liquid made from ingredients as simple as choline and acrylic acid? Scientists just used this eco-friendly combo to unlock flavonoids from a traditional herb, outperforming harsh solvents by up to four times.…

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Development of an electrochemical sensor using carbon nanotubes and hydrophobic natural deep eutectic solvents for the detection of α-glucosidase activity in extracts of autochthonous medicinal plants

Aschemacher N.A. · Talanta · 2024 · 25 citations

Imagine a sensor so sensitive it can detect a diabetes-related enzyme in medicinal plants—using a green solvent made from thyme and lactic acid. This is the first time such a combination has been used to build an electrochemical sensor.…

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The Effects of Selected Extraction Methods and Natural Deep Eutectic Solvents on the Recovery of Active Principles from Aralia elata var. mandshurica (Rupr. & Maxim.) J. Wen: A Non-Targeted Metabolomics Approach

Kaleta A. · Pharmaceuticals · 2024 · 24 citations

What if the greenest solvent could outperform traditional ones? A new study on Aralia elata reveals that a natural deep eutectic solvent, combined with a novel extraction method, unlocks a treasure trove of bioactive compounds.…

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The Versatility of NADES Across Applications

Freitas D.S. · Molecules · 2025 · 24 citations

Imagine a solvent that is green, cheap, and can be made from sugar and amino acids—welcome to the world of Natural Deep Eutectic Solvents (NADES), the unsung heroes of sustainable chemistry.…

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Enhancing bio-recovery of bioactive compounds extracted from Citrus medica L. Var. sarcodactylis: optimization performance of integrated of pulsed-ultrasonic/microwave technique

Mahdi A. · Journal of Food Measurement and Characterization · 2019 · 24 citations

What if the key to unlocking nature's most valuable compounds lies in a high-tech kitchen blender? A new study shows that combining ultrasound and microwaves can dramatically boost the extraction of health-boosting antioxidants from the Buddha's hand fruit.…

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Date pomace polysaccharide: ultrasonic-assisted deep eutectic solvent extraction, physicochemical properties, biological activities, gut microbiota modulation, and rheological properties

Bamigbade G.B. · Chemical and Biological Technologies in Agriculture · 2024 · 24 citations

What if the date pits you toss away could become a powerhouse of health-boosting compounds? Scientists just unlocked a treasure trove of bioactive polysaccharides from date pomace using a green, ultrasound-assisted method.…

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Root vegetable side streams as sources of functional ingredients for food, nutraceutical and pharmaceutical applications: The current status and future prospects

Zhou Y. · Trends in Food Science and Technology · 2023 · 22 citations

Every year, millions of tons of root vegetable scraps—peels, leaves, and pomaces—are thrown away or fed to animals, yet they hide a treasure trove of health-boosting compounds. What if these 'wastes' could become the next superfood ingredient or even a source of new medicines?…

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A comparative study on sequential green hybrid techniques (ultrasonication, microwave and high shear homogenization) for the extraction of date seed bioactive compounds and its application as an additive for shelf-life extension of Oreochromis niloticus

Osamede Airouyuwa J. · Ultrasonics Sonochemistry · 2024 · 20 citations

What if the secret to fresher fish lies in the humble date seed? A new study shows that green extraction techniques can unlock powerful antioxidants from this waste product, extending the shelf life of Nile tilapia.…

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Subcritical water extraction of salvia miltiorrhiza

Kapalavavi B. · Molecules · 2021 · 20 citations

Imagine boiling a medicinal herb for a thousand years—now imagine a greener, faster, and more potent way to unlock its healing power. That's the promise of subcritical water extraction, a technique that outshines the ancient art of herbal decoction.…

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In Silico-Assisted Isolation of trans-Resveratrol and trans-ε-Viniferin from Grapevine Canes and Their Sustainable Extraction Using Natural Deep Eutectic Solvents (NADES)

Kiene M. · Foods · 2023 · 19 citations

What if the key to unlocking grapevine's hidden treasures lies not in the lab, but in a computer simulation? Scientists are now using in silico methods to isolate powerful antioxidants from grapevine canes, reducing the need for tedious trial-and-error experiments.…

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Green Extraction of Bioactives from Curcuma longa Using Natural Deep Eutectic Solvents: Unlocking Antioxidative, Antimicrobial, Antidiabetic, and Skin Depigmentation Potentials

Jovanović J. · Plants · 2025 · 17 citations

Imagine a solvent so green it could make turmeric's golden treasures shine brighter than ever—without a drop of toxic chemistry. That's the promise of Natural Deep Eutectic Solvents, and they just outperformed plain water in unlocking turmeric's health secrets.…

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Investigating the influence of solvents and extraction methods on the efficacy of phenolic compound recovery from spent coffee grounds

Linhares Sabino N. · Separation and Purification Technology · 2025 · 17 citations

Your morning coffee leaves behind a treasure trove of bioactive compounds—if you know how to unlock them. A new study reveals the best solvents and methods to extract phenolic compounds from spent coffee grounds, turning waste into valuable ingredients for pharmaceuticals, cosmet…

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Natural Deep Eutectic Solvent-Based Matrix Solid Phase Dispersion (MSPD) Extraction for Determination of Bioactive Compounds from Sandy Everlasting (Helichrysum arenarium L.): A Case of Stability Study

Ivanović M. · Plants · 2022 · 16 citations

What if the key to unlocking plant power was a green, gooey liquid made from natural ingredients? A new study shows how a choline chloride-lactic acid mixture outperforms conventional solvents in extracting antioxidants from a resilient flower.…

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Green Extracts and UPLC-TQS-MS/MS Profiling of Flavonoids from Mexican Oregano (Lippia graveolens) Using Natural Deep Eutectic Solvents/Ultrasound-Assisted and Supercritical Fluids

Bernal-Millán M.d.J. · Plants · 2023 · 16 citations

What if the key to unlocking oregano's full antioxidant power lies not in traditional solvents, but in green, eco-friendly alternatives? A new study reveals that natural deep eutectic solvents, paired with ultrasound, outperform conventional methods—yet the old-fashioned approach…

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Studying and modeling of the extraction properties of the natural deep eutectic solvent and sorbitol-based solvents in regard to biologically active substances from glycyrrhizae roots

Boyko N. · Molecules · 2020 · 14 citations

What if the secret to unlocking nature's pharmacy lies not in exotic chemicals, but in a simple sugar alcohol? A new study reveals how sorbitol-based solvents can be fine-tuned to extract bioactive compounds from licorice roots with remarkable precision.…

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Combining the natural deep eutectic solvents and high-speed-shearing-enzymatic-assisted extraction to recover flavonoids and terpenoids from perilla leaves

Vo T.P. · Journal of Molecular Liquids · 2024 · 14 citations

What if the secret to unlocking nature's most valuable plant compounds was hiding in a simple, green solvent? A new study combines deep eutectic solvents with high-speed shearing and enzymes to recover flavonoids and terpenoids from perilla leaves—without the toxic chemicals.…

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Green and innovative extraction of polyphenols from Rhamnus alaternus using natural deep eutectic solvents and evaluation of their bioactivities

Nekkaa A. · Journal of Applied Research on Medicinal and Aromatic Plants · 2023 · 14 citations

What if the key to unlocking nature's antioxidant treasure chest lies not in harsh chemicals, but in a simple, eco-friendly mixture? A new study shows that natural deep eutectic solvents can efficiently extract polyphenols from a Mediterranean shrub, revealing potent bioactivitie…

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Green Extraction Approach for Isolation of Bioactive Compounds in Wild Thyme (Thymus serpyllum L.) Herbal Dust—Chemical Profile, Antioxidant and Antimicrobial Activity and Comparison with Conventional Techniques

Mrkonjić Ž. · Plants · 2024 · 14 citations

What if the dust left behind from wild thyme could be a treasure trove of natural compounds? A new study shows that a green extraction method can outperform traditional techniques, unlocking potent antioxidants and antimicrobials from this overlooked byproduct.…

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Evaluation of structurally different ionic liquid-based surfactants in a green microwave-assisted extraction for the flavonoids profile determination of mangifera sp. And passiflora sp. leaves from canary Islands

Moučková K. · Molecules · 2020 · 14 citations

What if the key to unlocking nature's hidden flavonoids lies in a liquid that's both green and surprisingly versatile? Scientists have found a way to extract these bioactive compounds from mango and passionfruit leaves using ionic liquid-based surfactants and microwaves—no harsh …

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Optimization of Ultrasonication Probe-Assisted Extraction Parameters for Bioactive Compounds from Opuntia macrorhiza Using Taguchi Design and Assessment of Antioxidant Properties

Kalompatsios D. · Applied Sciences Switzerland · 2024 · 13 citations

Move over, ordinary fruits—there's a cactus hiding a treasure trove of health-boosting compounds, and scientists just found the perfect way to unlock it. Red prickly pear, or Opuntia macrorhiza, is packed with polyphenols, ascorbic acid, and betalains, but only now are we learnin…

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The evaluation of five bioactive compounds content and in vitro antioxidant of Caryophylli Flos extracts obtained by natural deep eutectic solvents

Dong J. · Sustainable Chemistry and Pharmacy · 2022 · 12 citations

What if the key to unlocking nature's antioxidant power lies in a simple mixture of natural compounds? A new study reveals how Caryophylli Flos, the dried flower buds of clove, can be extracted using eco-friendly solvents to yield five bioactive compounds with promising antioxida…

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Simultaneous extraction and selective separation of catechins, caffeine and theanine from waste tea residue facilitated by citric acid-based deep eutectic solvent

Yang Y. · Separation and Purification Technology · 2025 · 12 citations

What if the leftover tea leaves in your cup could yield a treasure trove of health-boosting compounds? A new green method uses a citric acid-based solvent to simultaneously extract and separate catechins, caffeine, and theanine from waste tea residue.…

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Novel ternary deep eutectic solvent coupled with in-situ-ultrasound synergistic extraction of flavonoids from Epimedium wushanense: machine learning, mechanistic investigation, and antioxidant activity

Liu C. · Ultrasonics Sonochemistry · 2025 · 11 citations

What if the secret to unlocking nature's powerful flavonoids lies in a clever cocktail of everyday molecules, shaken not stirred, but blasted with sound? A new study harnesses just that to supercharge extraction from a traditional Chinese medicinal herb.…

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Natural Deep Eutectic Solvents (NADESs) for the Extraction of Bioactive Compounds from Quinoa (Chenopodium quinoa Willd.) Leaves: A Semi-Quantitative Analysis Using High Performance Thin-Layer Chromatography

Taco V. · Molecules · 2025 · 10 citations

What if the greenest way to unlock quinoa's health secrets is hiding in plain sight—in natural deep eutectic solvents? A new study shows these eco-friendly liquids can replace harsh petrochemicals to extract flavonoids and antioxidants from quinoa leaves.…

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Phenolic compounds detection and quantification in whole grains: A comprehensive review of recent advancements in analytical methods

Li H. · Trac Trends in Analytical Chemistry · 2025 · 10 citations

What if the key to unlocking hidden health benefits in whole grains lies not in the grains themselves, but in the sophisticated methods we use to see them? A new review reveals how cutting-edge analytical techniques are transforming our understanding of phenolic compounds—nature'…

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Optimization of Ultrasonic-Assisted Extraction of Antioxidants in Apple Pomace (var. Belorusskoje malinovoje) Using Response Surface Methodology: Scope and Opportunity to Develop as a Potential Feed Supplement or Feed Ingredient

Malenica D. · Sustainability Switzerland · 2024 · 10 citations

Your morning apple juice leaves behind a treasure trove of antioxidants—and scientists just found a greener way to unlock it. Could this overlooked waste become the next superfood for livestock?…

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Polyphenol-enriched extraction from Thunbergia laurifolia using natural deep eutectic solvents for enhanced antioxidant and anti-inflammatory activities

Srimawong C. · Rsc Advances · 2025 · 9 citations

What if the key to unlocking a plant's healing power lies not in harsh chemicals, but in nature's own green solvents? A new study reveals that swapping traditional ethanol for natural deep eutectic solvents can triple the polyphenol yield from a Southeast Asian medicinal herb.…

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Investigation of the Ability of Natural Deep Eutectic Solvents to Act as Efficient Extraction Media for Chamomille (Matricaria chamomilla L.)

Karadendrou M.A. · Food and Bioprocess Technology · 2025 · 8 citations

What if the key to unlocking nature's pharmacy lies not in harsh chemicals, but in a gentle, green solvent made from everyday molecules? A new study reveals that Natural Deep Eutectic Solvents (NADES) can double the extraction of beneficial compounds from chamomile compared to tr…

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Assessment of milling and the green biosolvents ethyl lactate and 2-methyltetrahydrofuran (2-methyloxolane) for the ultrasound-assisted extraction of carotenoids in common and phytoene-rich Dunaliella bardawil microalgae

Morón-Ortiz Á. · Lwt · 2024 · 8 citations

What if the key to unlocking nature's golden pigments lies not in harsh chemicals, but in greener, gentler solvents? A new study puts eco-friendly alternatives to the test against conventional ones, revealing a promising champion.…

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The total tannins of Geum japonicum Thunb. var. chinense extracted by green and natural deep eutectic solvent: Extraction optimization, component identification and hypoglycemic activity

Wang W. · Industrial Crops and Products · 2024 · 7 citations

What if the key to unlocking nature's medicine cabinet lies in a green, sugar-based solvent? A new study reveals how a natural deep eutectic solvent, paired with ultrasound, efficiently extracts bioactive compounds from a traditional herb, with rosmarinic acid as the star perform…

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Integrative analysis of Cichorium intybus L. Extracts: from NADES-Based extraction and UHPLC-Orbitrap®-HRMS to bioinformatics and machine learning

Sağlamtaş R. · Journal of Food Measurement and Characterization · 2026 · 7 citations

What if the key to unlocking a plant's hidden powers lies not in a harsh chemical, but in a natural, eco-friendly solvent? A new study on chicory reveals just that, using a 'green' solvent to boost beneficial compounds and predict their antioxidant strength with machine learning.…

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Green Method Comparison and Optimization of Anthocyanin Recovery from “Sangiovese” Grape Pomace: A Critical Evaluation of the Design of Experiments Approach

Lianza M. · Molecules · 2024 · 7 citations

Wine production leaves behind a treasure trove of bioactive compounds—if we know how to unlock them. This study pits green extraction methods against conventional ones to recover anthocyanins from grape pomace, revealing surprising trade-offs between yield and antioxidant activit…

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Enhanced Extraction and Separation with HPLC-DAD of Phenolic and Flavonoid Antioxidants from Portulaca oleracea L. Leaves Using Tailored Terpenoid-Based NADES: Comparative Assessment of Antiradical and Antimicrobial Activities

Sebbah T. · Antioxidants · 2025 · 7 citations

Imagine extracting nature's antioxidants with a solvent that's not only green but also outperforms traditional ethanol—this is exactly what terpenoid-based NADES achieve, doubling the yield of key bioactives from purslane leaves.…

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Towards a Green and Sustainable Valorization of Salix amplexicaulis: Integrating Natural Deep Eutectic Solvents and Microwave-Assisted Extraction for Enhanced Recovery of Phenolic Compounds

Vidić M. · Sustainability Switzerland · 2025 · 6 citations

What if the key to unlocking nature's pharmacy lies in a solvent made from sugar and lactic acid? A new study shows how a green cocktail can outperform traditional methods in extracting healing compounds from an overlooked willow species.…

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Natural Deep Eutectic Solvents vs. Conventional Solvents: Effects on Crude Yield, Mangiferin Content, Antioxidant Activity, and Toxicity in Mangifera pajang Kosterm. Fruit Extracts

Rosdan M.D.E.M. · Malaysian Applied Biology · 2025 · 6 citations

What if the secret to unlocking a wild mango's medicinal power lies not in the fruit itself, but in the green solvent used to extract it? A new study shows that natural deep eutectic solvents outperform traditional ones, boosting yield and antioxidant activity.…

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Evaluation of drying methods and green extraction techniques to enhance the recovery of bioactive compounds from hop leaves: A sustainable approach for the valorisation of agricultural by-products

Carbone K. · Ultrasonics Sonochemistry · 2025 · 6 citations

What if the leaves left behind after hop harvest—usually discarded as waste—could become a goldmine of health-boosting compounds? A new study shows how simple drying and green extraction choices can unlock that potential.…

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A green approach for the sustainable and effective valorization from Populus nigra buds as a renewable source of high value-added extract using an alternative solvent with prospective application in skin care formulation

Zaidi S. · South African Journal of Botany · 2023 · 6 citations

What if the key to better sunscreen was hiding in tree buds? Scientists have unlocked a green extraction method from black poplar buds that packs a powerful antioxidant punch—and could one day protect your skin.…

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Target-oriented rational design of composite bio-derived solvents for the green extraction of salvianolic acid B and tanshinones from Salvia miltiorrhiza root

Wang S. · Separation and Purification Technology · 2025 · 5 citations

What if the key to unlocking nature's pharmacy lies not in harsh chemicals, but in a green, tailor-made solvent? This study reveals how a custom-designed natural deep eutectic solvent outperforms traditional extraction, pulling out more active compounds from a medicinal root.…

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The Optimum Condition Design of Microwave-assisted Extraction Combined Lactic Acid-Sucrose Based Natural Deep Eutectic Solvent on Polyphenols Enrichment from Eleutherine bulbosa Mill. Urb. Bulbs

Ahmad I. · Journal of Research in Pharmacy · 2023 · 4 citations

What if the key to unlocking nature's pharmacy lies in a solvent made from lactic acid and sugar, powered by microwaves? This study reveals the optimal conditions to enrich polyphenols from a medicinal bulb using a green, natural deep eutectic solvent.…

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Green Approaches to Enhance Bioactive Compounds in Goji Berry (Lycium barbarum) Fruits: Comparative Optimization of Pressurized Water, Microwave-Assisted, and Ultrasound-Assisted Extraction Technologies by Using Response Surface Methodology

Yildiz-Ozturk E. · International Journal of Food Science · 2025 · 4 citations

Goji berries are ancient superfruits, but can we extract their magic without toxic solvents? A new study pits three green water-based techniques against each other to find the most potent and eco-friendly path.…

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Microwave-assisted deep eutectic solvent extraction and quantification of six bioactive compounds from Vaccinium vitis-idaea L. Leaves

Wang H. · Journal of Food Measurement and Characterization · 2025 · 3 citations

What if the key to unlocking nature's medicine cabinet lies in a simple, green solvent? A new study reveals that natural deep eutectic solvents (NADES) can extract more saponins from a traditional Chinese medicinal plant than conventional methods—and with greater diversity.…

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Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Simultaneous Extraction of Phenolic Acids and Flavonoids from Erigeron breviscapus and Its Extraction Mechanism Analysis

Zhang L. · ACS Sustainable Chemistry and Engineering · 2026 · 3 citations

What if the key to unlocking nature's pharmacy lies in a simple, green solvent? A new study harnesses ultrasonic waves and natural deep eutectic solvents to extract phenolic acids and flavonoids from Erigeron breviscapus, revealing the mechanism behind this efficient process.…

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Integrated Evaluation of NADES for Green Extraction of Bioactive Compounds from Strawberries: A Study on Anthocyanin, Antioxidant Activity, Chemometric FTIR Profiling

Ul Karimah A. · Trends in Sciences · 2026 · 2 citations

What if the key to unlocking nature's antioxidant treasure chest lies not in harsh chemicals, but in a simple mixture of natural compounds? A new study reveals that certain eco-friendly solvents can outperform traditional ethanol in extracting health-promoting compounds from stra…

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NADES and Ultrasound-Assisted Extraction for Recovery and Stability of Flavonoids from Ipomoea pes-caprae Leaves: Process Optimization, Phytometabolomics, Solvent Recyclability/Reusability, Stability Testing, and Mechanistic Insights

Sharma A. · ACS Food Science and Technology · 2026 · 2 citations

What if the key to unlocking nature's powerful flavonoids lies in a simple weed and a gentle ultrasound bath? This study shows how a green solvent system can extract and stabilize these compounds from Ipomoea pes-caprae leaves—without harsh chemicals.…

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Exploring the nutritional, phytochemical, and functional potential of African star apple (Chrysophyllum albidum) and its byproducts: A review of bioactivities and food applications

Adadi P. · Food Research International · 2026 · 2 citations

Hidden in West and Central Africa's forests lies a fruit so nutritious it could transform the way we eat—yet most of it rots before reaching a plate. Meet the African Star Apple, a neglected superfruit with a peel, pulp, and seed packed with polyphenols and promise.…

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Sustainable Extraction of Hedera helix Bioactive Compounds via Synergy of Natural Deep Eutectic Solvent and Ultrasound: Process Optimization, Mechanistic Insights and Anti-Colon Cancer Activity

Li T. · International Journal of Molecular Sciences · 2026 · 1 citations

What if the key to unlocking nature's cancer-fighting compounds lies in a simple mix of everyday chemicals and sound waves? A new study shows how this eco-friendly combo extracts powerful bioactives from ivy leaves with remarkable efficiency.…

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Consecutive Recovery of Bioactive Substances from Desmodium canadense at Different Plant Vegetation Phases by Green Extraction with Supercritical CO2 and Increasing Polarity Pressurized Liquids

Abbas S. · Molecules · 2026 · 1 citations

What if the same plant could give us two different treasure troves of antioxidants, simply by harvesting it at the right moment? Scientists just found that a humble weed, Desmodium canadense, hides a wealth of bioactive compounds that shift with its life cycle.…

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Sustainable Production and Characterization of Eumelanin from Organically Cultivated Mucuna ceniza Seeds: A High-Performance Biomaterial for Optoelectronic Applications

Herrera-Herrera P.A. · International Journal of Molecular Sciences · 2025 · 1 citations

What if a humble seed could power the next generation of electronic devices? Scientists have turned organic Mucuna ceniza seeds into a high-performance eumelanin, a natural pigment with extraordinary optoelectronic potential.…

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A liquid chromatographic time-of-flight tandem mass spectrometric method for the comparative study of propolis aqueous and cyclodextrin extracts employing target and suspect screening

Kalogiouri N.P. · Journal of Food Composition and Analysis · 2025 · 1 citations

What if the secret to unlocking propolis's health benefits lies not in harsh chemicals, but in plain water and a sugar derivative? A new study reveals how green solvents can extract these powerful compounds—and what they found might surprise you.…

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Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives

Shafiq M. · Marine Drugs · 2026 · 0 citations

Microalgae are tiny green factories with a big secret: they can produce valuable bioactive compounds—but only if we can crack their tough cell walls without burning the planet. Now, a new class of solvents called NADES is stepping into the spotlight, promising a greener path to u…

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Experiment-confirmed machine learning optimization of NADES extraction with ultrasound assistance and Mendelian randomization evidence on antioxidant effects of ferulic acid and ligustilide from Angelicae Sinensis Radix

Zhang Y. · Ultrasonics Sonochemistry · 2026 · 0 citations

What if a computer model could predict the perfect green recipe for extracting nature's most potent antioxidants? This study used machine learning to unlock the secrets of a traditional Chinese herb—and then proved it in the lab.…

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Interpretable machine learning for optimization of ultrasound-assisted polysaccharide extraction using natural deep eutectic solvents: From yield enhancement to structural and antioxidant activity validation

Zhang S. · Bioresource Technology · 2026 · 0 citations

What if a machine could tell us exactly how to unlock the antioxidant treasures hidden inside a flower? New research uses interpretable machine learning to optimize ultrasound-assisted extraction of polysaccharides with natural deep eutectic solvents—boosting yield while revealin…

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Green NADES–UAE four-Huang formula dissolving microneedles for acne vulgaris: Enhanced bioactivity with in vitro–in vivo anti-inflammatory efficacy

Chen M. · Journal of Drug Delivery Science and Technology · 2026 · 0 citations

What if the next breakthrough against acne isn't a pill or cream, but a tiny dissolving microneedle packed with green chemistry? A new study shows how a four-Huang formula, activated by ultrasound and natural deep eutectic solvents, fights inflammation with surprising power.…

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High voltage electrical discharge-assisted extraction of bioactive compounds from red onion peel (Allium cepa L.) using natural deep eutectic solvents: Efficiency, stability, and functional properties

Foroutani Z. · Applied Food Research · 2026 · 0 citations

A kitchen waste item just got a stunning upgrade: red onion peels, usually thrown away, can now be zapped with electricity and soaked in green solvents to unlock their hidden treasure trove of health-boosting compounds. This isn't just recycling—it's a high-voltage makeover for f…

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GLYCEROL-BASED NaDES FOR BIOACTIVE COMPOUND EXTRACTION FROM PRUNUS SPINOSA L. FRUIT: FORMULATION, CHARACTERIZATION, AND APPLICATION

Berkati A. · Annals of the University Dunarea De Jos of Galati Fascicle Vi Food Technology · 2025 · 0 citations

What if the key to unlocking nature's hidden treasures lies not in harsh chemicals, but in a simple, sweet molecule? Glycerol-based NaDES are emerging as green solvents that could revolutionize how we extract beneficial compounds from plants.…

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Green extraction and stabilization of bioactive compounds from annatto (Bixa orellana L.) seeds using hydrophobic natural deep eutectic solvents

Tessaro L. · Separation and Purification Technology · 2026 · 0 citations

What if the secret to a greener, more powerful extraction of nature's pigments was hiding in everyday fatty acids? Scientists have found a way to pull more color and stability from annatto seeds using a solvent that's both eco-friendly and remarkably effective.…

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Green extraction of natural antioxidant polyphenols from Celastrus orbiculatus using ultrasound-assisted deep eutectic solvents: Computational screening, process optimization, and mechanistic insights

Wang L. · Industrial Crops and Products · 2026 · 0 citations

What if the key to unlocking nature's antioxidants lies in a solvent that mimics plant cells? Scientists are using ultrasound and deep eutectic solvents to extract polyphenols from Celastrus orbiculatus more sustainably than ever before.…

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Ultrasound-Assisted Extraction of an Extract with Dermatological and Nosocomial Activity from Agave nuusaviorum, a Mexican Endemic Plant

García-Sánchez E. · Applied Sciences Switzerland · 2022 · 0 citations

What if a plant used in traditional Mexican medicine could be the next weapon against drug-resistant superbugs? A new study reveals that an ultrasound-assisted extract from Agave nuusaviorum leaves fights 14 different pathogens, including those causing skin and hospital infection…

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From Green Extraction to Gut Bioaccessibility: Synergistic Potential of Ginkgo biloba, Astragalus membranaceus, and Salvia miltiorrhiza Phytochemicals for Functional Food Applications

Younis M.I. · Food Science and Nutrition · 2026 · 0 citations

What if the key to unlocking nature's full medicinal power lies not in a single herb, but in a carefully orchestrated trio? A new study reveals that a specific blend of three traditional plants, extracted with green technology, might be a multitasking super-ingredient for functio…

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From Conventional Methods to Innovation: Caffeine and Chlorogenic Acid Extraction and Quantification in the Rise of Smart and Green Techniques—A Systematic Review

Awwad S.H. · Molecules · 2026 · 0 citations

Two molecules in your morning coffee are quietly shaping the future of green chemistry—one keeps you awake, the other fights oxidative stress. A new systematic review reveals how scientists are swapping old-school solvents for smarter, eco-friendly extraction methods.…

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Green Extraction of Anthocyanins from the Novel Anthocyanin-Rich BRS Carmem Grape: Multivariate Optimization, Bioactivity, Antimicrobial Potential, and Galleria mellonella Toxicity Assessment

de Vasconcelos Costa L. · Food Analytical Methods · 2026 · 0 citations

What if the secret to a sweeter, healthier life was hidden in a leaf—and a microwave could unlock it? Scientists just found a green way to extract a natural super-sweetener using eco-friendly solvents and a kitchen appliance.…

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Biorefinery-oriented green intensified extraction of bioactive blue pigment–protein complex from spirulina biomass via integrated deep eutectic solvents and microbubble-assisted ultrasound

Chaijaem P. · Applied Food Research · 2026 · 0 citations

What if the secret to a vibrant blue pigment could be unlocked with a greener, smarter approach? Scientists have found a way to extract spirulina's prized phycocyanin using deep eutectic solvents and microbubbles, making the process more sustainable and efficient.…

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