Alternative Assisted Extraction Methods of Phenolic Compounds Using NaDESs

What if the key to greener chemistry was hiding in natural compounds? Discover how deep eutectic solvents are transforming the way we extract phenolic compounds.

The industrial world is waking up to a greener reality, and solvents are at the heart of the change. Green analytical chemistry has introduced a new class of solvents that promise less harm and more efficiency. Among them, deep eutectic solvents (DESs) and their natural counterparts (NaDESs) stand out for their unique properties, offering a wide range of applications from cosmetics to pharmaceuticals.

This review zeroes in on the most innovative solvent-free extraction techniques: microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). These methods, combined with DESs and NaDESs, are proving to be powerful tools for pulling phenolic compounds from olive oil byproducts like pomace, leaves, and wastewater. The goal? To harness these bioactive phytochemicals—secoiridoids, lignans, phenolic acids, and alcohols—with precision and selectivity.

The evidence is compelling: DESs and NaDESs are not just eco-friendly alternatives; they are highly effective and selective. Studies on experimental design and process optimization are paving the way for their adoption. As the literature grows, these natural solvents are emerging as a viable substitute for petrochemicals, promising a cleaner, smarter future for extraction science.

Key Points

• NaDESs are green solvents for extracting phenolic compounds.
• MAE and UAE enhance extraction efficiency with NaDESs.
• NaDESs offer eco-friendly alternative to petrochemicals.