Green extraction and stabilization of bioactive compounds from annatto (Bixa orellana L.) seeds using hydrophobic natural deep eutectic solvents

Tessaro L. · Separation and Purification Technology · 2026 · 0 citations

What if the secret to a greener, more powerful extraction of nature's pigments was hiding in everyday fatty acids? Scientists have found a way to pull more color and stability from annatto seeds using a solvent that's both eco-friendly and remarkably effective.

Annatto seeds are a treasure trove of bioactive compounds, but traditional extraction relies on harsh organic solvents. Now, researchers have turned to hydrophobic natural deep eutectic solvents, or HNADES, as a sustainable alternative. These are essentially mixtures of saturated fatty acids that act as a multifunctional medium, simultaneously extracting and protecting delicate molecules like bixin and geranylgeraniol.

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