A simple and robust LC-ESI single quadrupole MS-based method to analyze polyphenols in plant extracts using deep eutectic solvents

Polyphenols are health heroes hiding in your plants—but finding them requires expensive, high-tech tools. Now, a simple method promises to change that.

Polyphenols—the antioxidants behind many of the health benefits of fruits, vegetables, and herbs—are notoriously tricky to analyze. They exist in complex plant matrices, making extraction and identification a challenge. Most precise methods rely on tandem mass spectrometry, but such high-resolution equipment is rare and costly. This leaves many labs without access to reliable polyphenol analysis.

Key Points

• Simple LC-ESI single-quadrupole MS method developed
• Analyzes 18 polyphenols: flavonoids, phenolic acids, anthocyanins
• Validated on three green-extracted plant extracts