Lactarius deliciosus Extract from Green Microwave-Assisted Eutectic Solvent Extraction as a Therapeutic Candidate Against Colon Cancer

What if a common edible mushroom could quietly outsmart colon cancer cells? A new study suggests that extracts from Lactarius deliciosus, the saffron milk cap, might just do that—without harming healthy gut barriers.

Digging deeper, the extract halted proliferation by inducing G0/G1 cell cycle arrest and apoptosis, linked to altered mitochondrial potential and increased caspase-3 activity. It also rebalanced the redox state by lowering ROS levels and dampened inflammation by downregulating NOS2 expression—all while leaving the intestinal barrier intact. The authors conclude that these bioactive compounds hold strong promise as anticancer and functional ingredients, offering a multitargeted approach against colon cancer.

Key Points

• Green microwave extraction with water or NaDES 1 maximizes phenolic recovery.
• Extract inhibits colon cancer cell growth, adhesion, and colony formation.
• Induces apoptosis and anti-inflammatory effects without harming intestinal barrier.