Green extraction of natural antioxidant polyphenols from Celastrus orbiculatus using ultrasound-assisted deep eutectic solvents: Computational screening, process optimization, and mechanistic insights

What if the key to unlocking nature's antioxidants lies in a solvent that mimics plant cells? Scientists are using ultrasound and deep eutectic solvents to extract polyphenols from Celastrus orbiculatus more sustainably than ever before.

The race for greener extraction methods just got a powerful ally. Researchers are turning to deep eutectic solvents (DES)—liquids made from natural components that are biodegradable and often food-grade. When paired with ultrasound assistance, these solvents can efficiently pull out valuable polyphenols from Celastrus orbiculatus, a plant known for its antioxidant potential.

But not just any solvent works. The team used computational screening to identify the most promising DES candidates before ever stepping into the lab. This smart pre-selection saves time and resources, ensuring that only the best solvents are tested experimentally. Then, process optimization fine-tuned the extraction conditions to maximize yield.

The results reveal a mechanism that goes beyond simple solubility. Ultrasound creates cavitation bubbles that disrupt plant cell walls, enhancing solvent penetration and mass transfer. This synergy between DES and ultrasound offers a sustainable, efficient pathway to natural antioxidants—paving the way for greener pharmaceuticals and nutraceuticals.

Key Points

• Deep eutectic solvents enable green extraction of polyphenols.
• Computational screening identifies optimal DES candidates efficiently.
• Ultrasound enhances extraction via cavitation and cell disruption.