A catalyst-free and eco-friendly approach to synthesis of 1,8-naphthyridines via natural deep eutectic solvents

What if the key to green chemistry was hiding in your kitchen? A natural mix of lactic acid, maltose, and amla juice is revolutionizing how we build complex molecules—no toxic catalysts needed.

The synthesized naphthyridines were confirmed by FTIR, NMR, and HRMS analyses. This work underscores the potential of natural-product-based DESs as sustainable media for multicomponent synthesis—a significant step forward for organic chemistry and green chemistry alike.

Key Points

• Lactic acid-maltose-amla DES enables catalyst-free synthesis.
• One-pot three-component reaction yields naphthyridines efficiently.
• Green solvent: biodegradable, low toxicity, recyclable.