Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement

Nature has provided brilliant ways to build molecules, but extracting and delivering them efficiently is a modern chemical puzzle. Could custom mixtures of natural compounds be the green key to unlocking better health supplements?

Plant-derived health products often face a major hurdle: many beneficial phytochemicals struggle with poor oral bioavailability. At the same time, the pharmaceutical and food industries urgently need greener, more eco-sustainable solvents. Enter Natural Deep Eutectic Solvents, or NADES. Formed entirely from everyday natural compounds like sugars, amino acids, and organic acids, these futuristic fluids might just change how we prepare nutraceuticals.

Researchers tested this potential using rutin, a well-known plant compound, as a model. By mixing various natural ingredients, the team discovered that specific combinations—like proline with glutamic acid or choline chloride—matched ethanol in their ability to dissolve rutin.

Next came the real test. When mice were given a proline/glutamic acid eutectic containing rutin, the results were striking. Using HPLC-MS/MS analysis, scientists tracked an increase in plasmatic levels of rutin, alongside a longer period of permanence in the bloodstream compared to a standard water suspension. This non-toxic approach points straight toward a greener, more effective future for drug and supplement design.

Key Points

• NADES offer eco-sustainable solvents for plant-derived pharmaceuticals
• Proline and glutamic acid mixtures successfully dissolve rutin
• NADES treatment increases rutin blood plasma levels and permanence