Monoterpenoid-Based Deep Eutectic Solvents/Natural Deep Eutectic Solvents: A Review on Its Characteristics and Applications

Imagine extracting nature's most valuable compounds using solvents that are as green as the plants they come from. Monoterpenoid-based deep eutectic solvents are rewriting the rules of sustainable chemistry.

Deep eutectic solvents (DES) and their natural counterparts (NADES) are emerging as heroes in the quest for greener extraction methods. A recent review, covering studies from 2020 to 2025, highlights their potential across industries, from extracting bioactive compounds and antioxidants to pulling natural pigments from food. These solvents are not just eco-friendly; they're versatile, pairing well with techniques like ultrasound, microwaves, and even supercritical carbon dioxide to boost efficiency. The review also notes that DES and NADES can be tailored by mixing monoterpenoids in precise molar ratios, using energy sources like conventional heating or microwave reactors. Yet, there's still uncharted territory: combining these solvents with supercritical CO2, studying their phase equilibrium, and understanding their thermophysical properties under varying conditions. These gaps offer exciting opportunities for innovation in health, pharmacy, chemistry, and beyond.

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