Microwave-assisted extraction of polyphenols from Eleutherine bulbosa Mill. Urb. bulbs using choline chloride-sorbitol based natural deep eutectic solvent

What if the secret to greener pharmaceuticals lies in a humble bulb and a pinch of sugar? Microwave-assisted extraction with a natural deep eutectic solvent just made polyphenol extraction faster, cleaner, and surprisingly simple.

Nature keeps surprising us. Eleutherine bulbosa, a plant long used in traditional medicine, is stepping into the spotlight as a raw material for herbal pharmaceuticals. But extracting its valuable polyphenols used to rely on harsh solvents. Now, scientists have swapped them for a green alternative: a natural deep eutectic solvent (NADES) made from choline chloride and sorbitol—two cheap, safe, and biodegradable compounds.

Key Points

• Optimum MAE: 1:1 NADES ratio, 5 min, 20% power, 12:1 liquid-solid.
• Scale-up yielded 39.88 mg GAE/g polyphenols from 50 g sample.
• Green NADES extraction is efficient, rapid, and eco-friendly.