Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

For centuries, Artemisia argyi leaves have been a staple in traditional medicine—but their healing phenolic acids have never been efficiently extracted. Now, tailor-made green solvents are changing that.

Artemisia argyi leaves have been used for centuries in Asian traditional medicine and as a food supplement. Among their many bioactive compounds, phenolic acids stand out as the main active ingredients—yet no one had developed a dedicated extraction method for them until now.

Key Points

• Ternary DES (choline chloride:malic acid:urea, 2:1:2) boosts yields.
• Optimized conditions: 23.5 min, 57.5 mL/g, 54% water.
• Green alternative to conventional organic solvents.