Advancing sustainable phytochemical extraction through design of experiments: A data-driven pathway toward low-emission natural product processing

What if a simple statistical tool could make herbal extraction up to 500% more efficient while slashing solvent use and time? That's the promise of Design of Experiments (DOE) in green chemistry.

The push for sustainable natural products has put green extraction methods in the spotlight. This review zeroes in on Design of Experiments (DOE), especially via Design Expert® software, as a game-changer in optimizing phytochemical extraction. By comparing techniques like microwave-assisted, ultrasound-assisted, enzyme-assisted, and supercritical fluid extraction, DOE shows how to boost yields, cut solvent use, and shorten processing times—all while keeping compounds intact.

Key Points

• DOE boosts extraction efficiency up to 500%.
• Central composite and Box–Behnken designs excel.
• Integrates risk tools and green metrics for compliance.