Sustainable ultrasound-assisted extraction of osthole from Cnidum monnieri (L.) Cuss based on natural deep eutectic solvents and switchable hydrophilicity solvents

Imagine extracting a precious medicinal compound from a plant using solvents that are not only green but also switchable—this is now a reality for osthole from Cnidium monnieri.

Osthole, a bioactive coumarin found in Cnidium monnieri, has long been valued for its therapeutic potential. However, traditional extraction methods often rely on volatile organic solvents, raising environmental concerns. This study introduces a sustainable alternative: ultrasound-assisted extraction using natural deep eutectic solvents (NADES) combined with switchable hydrophilicity solvents (SHS). The approach not only reduces environmental impact but also enhances extraction efficiency. By optimizing conditions—such as solvent composition, ultrasound time, and temperature—the researchers achieved high osthole yields. The switchable solvents allow for easy recovery and reuse, making the process more economical and eco-friendly. This green methodology represents a significant step forward in sustainable phytochemical extraction, offering a model for other bioactive compounds.

Key Points

• Ultrasound-assisted extraction using NADES and SHS.
• Sustainable method for osthole from Cnidium monnieri.
• Optimized conditions yield high osthole recovery.