Neuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction

Millions of tons of orange peel waste could hold the key to protecting the brain—if we stop throwing it away. Scientists have found a way to turn juice by-products into a neuroprotective powerhouse.

The winning formula was simple: extract at 100°C for 30 minutes. This yielded an extract with strong antioxidant power, potent anti-cholinesterase activity, and low cytotoxicity. Even better, it protected cells against L-glutamic acid-induced damage, a common model for neurodegeneration. This isn't just waste management—it's a potential pathway to new neuroprotective therapies, straight from the juicer.

Key Points

• Orange peel waste yields neuroprotective terpenoid-rich extracts.
• Optimized extraction at 100°C for 30 minutes works best.
• Extracts show antioxidant, anti-inflammatory, and anti-cholinesterase activity.